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Medical transition is a part of transition in which a transgender person undergoes medical treatments so that their sex characteristics better match their gender identity. Medical transition can be described as feminising (for transfeminine people), masculinising (for transmasculine people) or gender neutralizing, where sex characteristics are removed or made androgynous, which may be desired by non-binary people, especially those who are agender or neutrois.

Medical transition generally requires the approval of a doctor before treatment can begin. This often means that one must be diagnosed with Gender Identity Disorder before being able to transition medically. Some doctors require a social transition to have been completed for at least a year before surgery can take place. These restrictions are a form of gatekeeping.

Examples of procedures involved in medical transition may include:

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